The Nettle has been life changing as someone with pcos and pmdd, and long term depression. It’s helped me to manage my mood and reduced my pain symptoms. It’s not like any other treatment I have exper... See more
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Samphire Neuroscience is a neurotechnology company dedicated to maximizing the wellbeing of women by delivering pioneering neurotechnology and evidence-based solutions that are drug and hormone-free. Our products include Nettle™, a medically-approved brain stimulation device to tackle PMS and menstrual pain non-invasively, Lutea™, a wellness brain stimulation device to support women during hormonally challenging moments, and the Samphire App, which helps women understand the patterns behind their cycles.
85 Great Portland Street, W1W 7LT, London, United Kingdom
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Nettle is a revolutionary device for taking back the responsabilitues of our health. It s wonderfull to manage ans schedule a session with nettle the moment u need it.
It is very efficient because we can act daily on our pain and discomfort.

Reply from Samphire Neuroscience
I’ve used nettle for a year now and have noticed a significant difference in my symptoms during my luteal phase. App is easy to use and helpful to track my symptoms !

Reply from Samphire Neuroscience
nettle has been such a great addition to my PMDD treatment, truly not much actually works and especially not without side effects. my nettle (while absolutely not 100% effective), takes the edge off to a more manageable level and is really easy to keep up with as part of my routine. also reduces my cramps a bit which I honestly wasn’t expecting at all! i love that this is a women’s team too, our health is so under-researched, and everyone from samphire has been incredibly responsive when I’ve needed it. looking forward to seeing how this continues to develop!

Reply from Samphire Neuroscience
Fantastic customer service, first of all. I had some questions and immediately got answers from Em. It helped so much as I was overwhelmed at first and was scared to do something wrong, but she went through it all with me and I felt so much more confident using it. I have only recently started using the Nettle regularly (after setting up notifications in the app so it reminds me when I need to use it), so I can’t say just yet how much it’s improving my symptoms of PMDD moods and Endometriosis pain, but after being offered the only treatment option of chemically induced menopause by nhs, and declining that, I’m just so happy to have this device as alternative treatment for these very overlooked and underesearched conditions. I’m very hopeful it will help because there are so many positive reviews and Em is very knowledgeable on these conditions. The device is comfortable and easy to use. Once you’ve used it a few times it becomes second nature to go through the steps. It tingles and itches a bit at first but that only lasts a minute for me and then it’s unnoticeable! I can’t wait to see how this device helps me.

Reply from Samphire Neuroscience
Nettle is a game changer.
I've had it for a year now and it has helped massively with my PMDD. I find it extremely helpful around 10-7 days before my cycle when I feel the most erratic. The feeling when your mind is racing is tuned down almost instantly after using it and I can think in single sentences again.
It helps with endo in reducing the amount of painkillers I take, but I am not really very consistent with it due to my lifestyle/job. I could probably get better results being more consistent.

Reply from Samphire Neuroscience
Using Nettle has been a life saver. I use it on days that my symptoms flare, which for me can also be around ovulation. I can feel relief midway through a session sometimes. It has eased cramps and pain, and mostly been incredible for my mood. It has taken the edge off when I’m really spiraling and has brought me back into a regulated state from a very depressed and overwrought place. I have had less suicidal ideation since using it, and when I did feel it, the Nettle device helped bring my thinking back down into a safe place. I’m very thankful and grateful that it exists.
If you are on the fence (like I was because I was a bit worried about messing with my brain) I would highly recommend trying it because it has improved my life and given me a tool. Before I felt alone in dealing with PMDD, even when consulting professionals. I tried therapy, diet changes, birth control, SSRIs, and supplements. Nettle has done more for me than any of the other interventions I’ve tried and in a faster period of time.
Also Samphire seems like a wonderful company. Their customer service is stellar and responsive. They really care about women’s health and want to improve lives. The app is lovely and I now use that to track everything and am getting better data about my cycle and trends.

Reply from Samphire Neuroscience
Samphire has been a very supportive company to work with! Any time I've had questions they've responded quickly. And I do think my Nettle does help with my PMDD.

Reply from Samphire Neuroscience
I use Nettle since January and after a few problems I found my rhythm of using and it helps a lot with my symptoms. I also have adhd and I‘m autistic and I have the feeling, that nettle makes me calmer. The best thing of nettle are the people behind it. The Team is so fantastic and passionate.

Reply from Samphire Neuroscience
Nettle has been such a welcome addition to my PMDD treatment. I love that this has been designed and made by women, for people who are often forgotten by our patriarchal medical systems. Firstly, the team go above and beyond – the care and support is next level, it’s personalised, it’s prompt and I trust the team want the best for me. I do multiple things to manage my PMDD, so it’s hard to pin down the effect of individual treatments, however I can say this has definitely helped raise the floor and level out the extreme drops. Sometimes when I’m having good month and use Nettle anyway, I feel more energised and alert. It’s also a good comfort-blanket to know I have something science-backed and non-invasive whenever I need it. I love that the app gets updated from us, the community. I’ve had a couple of suggestions implemented and that feels wonderful to be part of! No big-pharma or tech-bros over here. Love your work team ❤️

Reply from Samphire Neuroscience
My experience wasn't smooth from the beginning. I wasn't able to connect Nettle with my personal smartphone. It only worked with other smartphone. And the app itself acts very strange, one time all texts and images/videos are visible, other time no images/videos visible and even text on buttons are not fully visible, it is happening when trying to run session with instruction step by step. Also resently Nettle starts not turning on even it was charged over the night. And I was needed to recharge it again. And next day it is happening again I need to recharge to be able start a session.
I still have hope that it will help me. It is only two cycles of period past, so I can't say if it is really helping. Maybe the mood is better. But still no affection to pain strenght.

Reply from Samphire Neuroscience
I suffer from PMDD and Nettle has been a lifesaver for me! For 2 weeks of every month I used to suffer from extreme anxiety and depression that was debilitating. Since using Nettle my symptoms are so much more manageable. It’s really helped me when I felt I was running out of options. Also, the team that run it are amazing people, they are always there to answer any questions you may have and you can tell they really care! Cannot recommend this product enough!

Reply from Samphire Neuroscience
Since joining Samphire and getting the Nettle headband, my life has changed so much. I suffer with PMDD and my periods can vary however since using Nettle, I have seen a significant decrease in physical and mental symptoms and it’s not half as bad as what it’ll my symptoms could be. I’m still quite new to nettle but I honestly won’t ever go without it. Thank you so much to the team at Samphire.

Reply from Samphire Neuroscience
Nettle has completely transformed my life. My PMDD symptoms are significantly reduced and whilst not completely gone, what felt like drowning in a storm now feels like navigating it in a pretty sturdy ship.
I feel like I have more control over my symptoms, I’m able to do more of the things that I do outside of luteal phase, and I have more mental clarity. Instead of my cycle feeling like two opposite ends of the spectrum, it now feels more balanced and less like I have to spend the first week of my cycle recovering from luteal the week before.
Thank you so much Samphire Neuroscience. I discovered Nettle through a Queen Mary University trial and I hope one day for all people who experienced PMDD that it will be available on the NHS. It truly has changed my life

Reply from Samphire Neuroscience
Samphire is a startup exactly as it should be: delivering an innovative and truly needed product in the way customers actually need it. They stay close, listen carefully to feedback and respond quickly whenever improvements are required.
I’m very satisfied with both the product and the service — highly recommended!

Reply from Samphire Neuroscience
Absolutely life changing device. I have seen such a difference in my symptoms since using this. Less pain, fewer mental health concerns. Customer service has been impeccable.

Reply from Samphire Neuroscience
Amazing customer service and support. Nettle has helped with my PMDD symptoms and would highly recommend it to others.

Reply from Samphire Neuroscience
I have now been using Nettle for over a year and it is life changing.
PMDD symptoms are vastly reduced.
It is very easy to use, I have very thick hair and it hasn’t been an issue.
Customer service are very responsive and were very helpful when I had charging issues.

Reply from Samphire Neuroscience
I’m one of the early buyers of the Nettle neurostimulation headband in France, and I’ve been using it since the very beginning. I can honestly say it has completely changed the way I experience my period.
I used to have extremely painful periods — the kind that forced me to take painkillers every single month since my very first cycle. I’m 30 now, and since I started using Nettle, I haven’t taken a single painkiller. For me, that alone is absolutely huge. Some months my pain goes down to almost zero, and even on the more difficult ones, it’s still nothing compared to what I used to go through.
For mood regulation, I didn’t notice a major improvement. However, knowing that my pain will be low or manageable has removed a lot of the fear and anxiety I used to feel before my cycle. That in itself has made the whole experience emotionally easier.
I also noticed that my period flow has become much lighter — I can’t say for sure if this is related to Nettle, but it has been consistent since I started using it.
I have experienced ongoing technical issues with the device and had to send it back multiple times. But the Samphire team has always been incredibly responsive and helpful. They answered quickly, guided me through the process, and always found a solution. Their customer service really stands out.
Even with the technical problems, I genuinely believe this headband has drastically changed my life, and I truly wish it could be known and accessible to every woman who struggles with period pain.

Reply from Samphire Neuroscience
Most incredible decision I have made to support my health. My pain is much more manageable, my quality of life has improved drastically. Also, the customer support is out of this world. I recommend this to everyone I believe it could be useful for. Incredible 100/10!

Reply from Samphire Neuroscience
Using a Nettle has changed my life. The week before my period, are now doable.
Before Nettle, I felt overwhelmed, anxious and even angry the week before my period. Now that's replaced with a bit of tiredness and most importantly my happiness stays throughout my cycle.
This headband is an absolute game changer!! I am literally recommending it to any woman, who deals with an overwhelming luteal phase.
Thank you so much Samphire Neuroscience, everyone I have been in contact with has been so helpful and kind.

Reply from Samphire Neuroscience
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